解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
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泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intrav...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cww038
更新日期:2016-08-01 00:00:00
abstract::UDP-N-acetylglucosamine (UDP-GlcNAc) is a glucose metabolite with pivotal functions as a key substrate for the synthesis of glycoconjugates like hyaluronan, and as a metabolic sensor that controls cell functions through O-GlcNAc modification of intracellular proteins. However, little is known about the regulation of h...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww019
更新日期:2016-07-01 00:00:00
abstract::The enzyme UDP-N-acetylglucosamine: α-d-mannoside β-1-6 N-acetylglucosaminyltransferase V (GnT-V) catalyzes the transfer of GlcNAc from the UDP-GlcNAc donor to the α-1-6-linked mannose of the trimannosyl core structure of glycoproteins to produce the β-1-6-linked branching of N-linked oligosaccharides. β-1-6-GlcNAc-br...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww010
更新日期:2016-07-01 00:00:00
abstract::Apiose is a unique branched-chain pentose found principally in plants. It is a key component of structurally complex cell wall polysaccharides, as well as being present in a large number of naturally occurring secondary metabolites. This review provides a comprehensive overview of the current state of knowledge on the...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cww012
更新日期:2016-05-01 00:00:00
abstract::A large family of UDP-GalNAc:polypeptide GalNAc transferases (ppGalNAc-Ts) initiates and defines sites of mucin-type Ser/Thr-O-GalNAc glycosylation. Family members have been classified into peptide- and glycopeptide-preferring subfamilies, although both families possess variable activities against glycopeptide substra...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv108
更新日期:2016-04-01 00:00:00
abstract::There is increasing evidence that secretory fluids such as tears, saliva and milk play an important role in protecting the human body from infection via a washing mechanism involving glycan-mediated adhesion of potential pathogens to secretory glycoproteins. Interaction of sweat with bacteria is well established as th...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwv102
更新日期:2016-03-01 00:00:00
abstract::The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) a...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv082
更新日期:2016-02-01 00:00:00
abstract::Mycobacterium tuberculosis lipoarabinomannan (LAM) and biosynthetically related lipoglycans and glycans play an important role in host-pathogen interactions. Therefore, the elucidation of the complete biosynthetic pathways of these important molecules is expected to afford novel therapeutic targets. The characterizati...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv061
更新日期:2015-11-01 00:00:00
abstract::F-type lectins are fucolectins with characteristic fucose and calcium-binding sequence motifs and a unique lectin fold (the "F-type" fold). F-type lectins are phylogenetically widespread with selective distribution. Several eukaryotic F-type lectins have been biochemically and structurally characterized, and the F-typ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv029
更新日期:2015-08-01 00:00:00
abstract::N-Glycanase 1, encoded by NGLY1, catalyzes the deglycosylation of misfolded N-linked glycoproteins retrotranslocated into the cytosol. We identified nine cases with mutations in NGLY1. The patients show developmental delay, seizures, peripheral neuropathy, abnormal liver function and alacrima (absence of tears). The m...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv024
更新日期:2015-08-01 00:00:00
abstract::N-Glycans from the nematode Haemonchus contortus (barber pole worm), a parasite of sheep and cattle, were the first to be described to possess up to three fucose residues associated with the N,N'-diacetylchitobiosyl core, two being on the reducing-terminal proximal GlcNAc and one on the distal core GlcNAc residue. The...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwv015
更新日期:2015-06-01 00:00:00
abstract::Macrophages are major cells of inflammatory process and take part in a large number of physiological and pathological processes. According to tissue environment, they can polarize into pro-inflammatory (M1) or alternative (M2) cells. Although many evidences have hinted to a potential role of cell-surface glycosaminogl...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu137
更新日期:2015-05-01 00:00:00
abstract::Glycoside hydrolases are particularly abundant in all areas of metabolism as they are involved in the degradation of natural polysaccharides and glycoconjugates. These enzymes are classified into 133 families (CAZy server, http://www.cazy.org) in which members of each family have a similar structure and catalytic mech...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu121
更新日期:2015-04-01 00:00:00
abstract::Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. Macrophage-secreted factors includi...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu112
更新日期:2015-03-01 00:00:00
abstract::Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Diagnosis of this infection frequently employs detection of the circulating galactomannan in the patient serum using enzyme immunoassay (EIA), a highly sensitive and specific system. Although there are many structura...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu091
更新日期:2015-01-01 00:00:00
abstract::Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we d...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwu054
更新日期:2014-10-01 00:00:00
abstract::Genetic polymorphism studies in humans provide unique opportunities to understand human biology and the mechanisms of diseases. Correlations between polymorphisms in the genes encoding human Siglecs and various diseases have been reported. Leading examples, such as the CD33 polymorphism associated with late-onset Alzh...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwu043
更新日期:2014-09-01 00:00:00
abstract::Schistosomiasis caused by infection with parasitic helminths of Schistosoma spp. is a major global health problem due to inadequate treatment and lack of a vaccine. The immune response to schistosomes includes glycan antigens, which could be valuable diagnostic markers and vaccine targets. However, no precedent exists...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu027
更新日期:2014-07-01 00:00:00
abstract::O-Acetylglucuronoxylans (AcGX) in Arabidopsis thaliana carry acetyl residues on the 2-O and/or 3-O positions of the xylopyranosyl (Xylp) units, but the distribution of different O-acetylated Xylp units is partly unclear. We studied a possible correlation of xylan acetylation and the activities of different glycosyltra...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu017
更新日期:2014-06-01 00:00:00
abstract::Hypertrophy is central to several heart diseases; however, not much is known about the role of glycosphingolipids (GSLs) in this phenotype. Since GSLs have been accorded several physiological functions, we sought to determine whether these compounds affect cardiac hypertrophy. By using a rat cardiomyoblast cell line, ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu020
更新日期:2014-06-01 00:00:00
abstract::The structure of a antigen-binding fragment (Fab) from the bactericidal monoclonal antibody LPT3-1 specific to lipooligosaccharide (LOS) inner cores from Neisseria meningitidis has been solved in complex with an eight-sugar inner core fragment NmL3 galE lpt3 KOH to 2.69 Å resolution. The epitope is centered about an i...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu009
更新日期:2014-05-01 00:00:00
abstract::The syp locus includes four genes encoding putative regulators, six genes encoding glycosyltransferases, two encoding export proteins, and six other genes encoding unidentified functional proteins associated with biofilm formation and symbiotic colonization. However, the individual functions of the respective genes re...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu001
更新日期:2014-04-01 00:00:00
abstract::β-Glucans possess broad immunomodulatory properties, including activation of innate immune functions such as oxidative burst activity. The differential roles of complement receptor type 3 (CR3) and Dectin-1, the known β-glucan receptors, and their associated signaling pathways in the generation of oxidative burst indu...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwu005
更新日期:2014-04-01 00:00:00
abstract::Neisseria meningitidis serogroups A, B, C, Y, W135 and X are responsible for most cases of meningococcal meningitis. Neisseria meningitidis serogroup X has recently emerged as a contributor to outbreaks of disease in Africa, but there is currently no vaccine against serogroup X. Understanding of the biosynthesis of th...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt091
更新日期:2014-02-01 00:00:00
abstract::Neisseria meningitidis (Nm) is a leading cause of bacterial meningitis and sepsis. A key feature in pathogenicity is the capsular polysaccharide (CPS) that prevents complement activation and thus supports bacterial survival in the host. Twelve serogroups characterized by immunologically and structurally different CPSs...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt102
更新日期:2014-02-01 00:00:00
abstract::Mechanisms for nonenzymatic protein glycation have been extensively studied albeit with an emphasis at the later stages that gives rise to advanced glycation end products. No detailed investigation of the initial, noncovalent binding of d-glucose to human hemoglobin A (HbA) exists in the literature. Although anionic m...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt061
更新日期:2013-11-01 00:00:00
abstract::Human milk oligosaccharides (HMOS) are not digested in the proximal intestine. In distal intestine, HMOS collectively modify the microbiota, but the response of individual bacteria to individual components of the HMOS is not well defined. Here, each of 25 major isolates of the human intestinal microbiota was fed indiv...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt065
更新日期:2013-11-01 00:00:00
abstract::At weaning, the intestinal mucosa surface glycans change from predominantly sialylated to fucosylated. Intestinal adaptation from milk to solid food is regulated by intrinsic and extrinsic factors. The contribution by glucocorticoid, an intrinsic factor, and colonization by microbiota, an extrinsic factor, was measure...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt050
更新日期:2013-10-01 00:00:00
abstract::Glycosphingolipids are expressed on the cell membrane and act as important factors in various events that occur across the plasma membrane. Lactosylceramide (LacCer) is synthesized from glucosylceramide and is a common precursor of various glycosphingolipids existing in whole body. Based on the enzyme purification, β1...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt054
更新日期:2013-10-01 00:00:00
abstract::Trehalose synthase (TreS) catalyzes the reversible conversion of maltose into trehalose in mycobacteria as one of three biosynthetic pathways to this nonreducing disaccharide. Given the importance of trehalose to survival of mycobacteria, there has been considerable interest in understanding the enzymes involved in it...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt044
更新日期:2013-09-01 00:00:00
abstract::The human intestine houses a dense microbial ecosystem in which the struggle for nutrients creates a continual and dynamic selective force. Host-produced mucus glycans provide a ubiquitous source of carbon and energy for microbial species. Not surprisingly, many gut resident bacteria have become highly adapted to effi...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwt040
更新日期:2013-09-01 00:00:00
abstract::In this work, focused on possible application of α-L-fucosidases from bacterial sources in the synthesis of α-L-fucosylated glycoconjugates, several nonpathogenic aerobic bacterial strains were screened for α-L-fucosidase activity. Among them Paenibacillus thiaminolyticus was confirmed as a potent producer of enzyme w...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt041
更新日期:2013-09-01 00:00:00
abstract::The specificities of glycosaminoglycan (GAG) modification enzymes, particularly sulfotransferases, and the locations and concentrations of these enzymes in the Golgi apparatus give rise to the mature GAG polysaccharides that bind protein ligands. We studied the substrate specificities of sulfotransferases with a stabl...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt033
更新日期:2013-08-01 00:00:00
abstract::The leguminous-type (L-type) lectin ER-Golgi intermediate compartment (ERGIC)-53, a homo-oligomeric endoplasmic reticulum (ER)-Golgi recycling protein, functions as a transport receptor for newly synthesized glycoproteins in the early secretory pathway. Although a limited subset of cargo glycoproteins transported by E...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt027
更新日期:2013-07-01 00:00:00
abstract::Endolysins are bacteriophage enzymes that lyse their bacterial host for phage progeny release. They commonly contain an N-terminal catalytic domain that hydrolyzes bacterial peptidoglycan (PG) and a C-terminal cell wall-binding domain (CBD) that confers enzyme localization to the PG substrate. Two endolysins, phage ly...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt019
更新日期:2013-07-01 00:00:00
abstract::The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be disialylated. In contrast, a disialy...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt008
更新日期:2013-06-01 00:00:00
abstract::The product of p53-induced gene 1 is a member of the galectin family, i.e., galectin-7 (Gal-7). To move beyond structural data by X-ray diffraction, we initiated the study of the lectin by nuclear magnetic resonance (NMR) and circular dichroism spectroscopies, and molecular dynamics (MD) simulations. In concert, our r...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwt005
更新日期:2013-05-01 00:00:00
abstract::The glycobiology of the cestodes, a class of parasitic flatworms, is still largely unexplored. An important cestode species is Echinococcus granulosus, the tissue-dwelling larval stage of which causes hydatid disease. The E. granulosus larva is protected from the host by a massive mucin-based extracellular matrix term...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cws220
更新日期:2013-04-01 00:00:00
abstract::Shigella flexneri is the major human pathogen causing shigellosis. O-antigens of all S. flexneri serotypes (except for serotype 6) share the →2)-α-l-Rhap(III)-(1 → 2)-α-l-Rhap(II)-(1 → 3)-α-l-Rhap(I)-(1 → 3)-β-d-GlcpNAc-(1→ basic O-unit, whereas differences between the serotypes are conferred by phage-encoded glucosyl...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cws222
更新日期:2013-04-01 00:00:00
abstract::Circulating leukocytes that express selectin ligands such as the carbohydrate epitope sialyl Lewis X (sLeX) may interact with endothelial selectins, resulting in transmigration of the leukocyte across the endothelial wall to adjacent tissue. Due to the potential of selectin-ligand interactions as targets in viral path...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cws160
更新日期:2013-03-01 00:00:00